This is important, you need to look at your total environment to see what changed. It could be anything from air pollution, diet, EMFs. Anxiety always has a trigger and it is not always psychological.
> I'm definitely curious as to how you got to such a nuanced diagnosis / underlying mechanism for your anxiety.
I went through everything you did, but once I noticed so many people were doing the woo woo route and nothing helped, so I decided to learn about neurobiology, genetics and nutrition. Almost everything you will read about anxiety and mood is wrong. (For example, low serotonin is the result of high GABA, and it is the high GABA that causes depression, not the low serotonin or dopmaine, that is just a result of the low GABA. https://www.nature.com/articles/s41380-022-01730-4)
I was anxious as a child, and had OCD, so I knew it was genetics. My mother had mental health issues as well all up her side of the family. 20 years ago I ended up on disability and doctors were of little help, just felt drugged all the time, so I set off to research neurobiology since I had the spare time and lived next to a university research hospital.
Then when 23andMe appeared I jumped on it and it was all right there. But it took years for more research to come out which narrowed in on my problem. First it was genes like CACNA1C and SLC6A4, but when I saw many immune genes linking to my Ankylosing Spondylitis (ERAP1) it became a bit more confusing. I kept seeing so many genes that needed zinc flagging in my genome. High does zinc fixed my autoimmune issues, as did long chain omega 3 (FADS1, FADS2 also linked to mood). But the studies I began to read about NOS1AP matched my genetics so I dove head first into that pathway at it ll became clear how glutamate was casueing my anxiety and paranoina and psychosis.
I also have changes in GCH1 that controls the amount of serotoin and dopmaine we make. I am in a study at Stanford as they feel it is linked to ME/CFS. I was diagnosed with CFS years ago but I only have infrequent symptoms now.
I have one doctor who knows I know what I am talking about and gets me some tests that might help me see what is going on but this is all research level stuff, nothing and doctor will see for years if ever. I am on Medicare, fully disabled, so it is hard for her to get some weird tests but she tries. She also helps me get meds I feel might help that might not be her first thought. But meds are no answer, they work until they do not.
Glutamate/GABA imbalance and nitric oxide will soon be recognized as the drivers of mood disorders.
I am confidant I am right because all my friends have see the change in me. Plus I no longer needs meds.
If I had you genetics I could probably see what is going on with you. Let me know if you want me to take a look: followingthedao@fastmail.com
This is important, you need to look at your total environment to see what changed. It could be anything from air pollution, diet, EMFs. Anxiety always has a trigger and it is not always psychological.
> I'm definitely curious as to how you got to such a nuanced diagnosis / underlying mechanism for your anxiety.
I went through everything you did, but once I noticed so many people were doing the woo woo route and nothing helped, so I decided to learn about neurobiology, genetics and nutrition. Almost everything you will read about anxiety and mood is wrong. (For example, low serotonin is the result of high GABA, and it is the high GABA that causes depression, not the low serotonin or dopmaine, that is just a result of the low GABA. https://www.nature.com/articles/s41380-022-01730-4)
I was anxious as a child, and had OCD, so I knew it was genetics. My mother had mental health issues as well all up her side of the family. 20 years ago I ended up on disability and doctors were of little help, just felt drugged all the time, so I set off to research neurobiology since I had the spare time and lived next to a university research hospital.
Then when 23andMe appeared I jumped on it and it was all right there. But it took years for more research to come out which narrowed in on my problem. First it was genes like CACNA1C and SLC6A4, but when I saw many immune genes linking to my Ankylosing Spondylitis (ERAP1) it became a bit more confusing. I kept seeing so many genes that needed zinc flagging in my genome. High does zinc fixed my autoimmune issues, as did long chain omega 3 (FADS1, FADS2 also linked to mood). But the studies I began to read about NOS1AP matched my genetics so I dove head first into that pathway at it ll became clear how glutamate was casueing my anxiety and paranoina and psychosis.
I also have changes in GCH1 that controls the amount of serotoin and dopmaine we make. I am in a study at Stanford as they feel it is linked to ME/CFS. I was diagnosed with CFS years ago but I only have infrequent symptoms now.
I have one doctor who knows I know what I am talking about and gets me some tests that might help me see what is going on but this is all research level stuff, nothing and doctor will see for years if ever. I am on Medicare, fully disabled, so it is hard for her to get some weird tests but she tries. She also helps me get meds I feel might help that might not be her first thought. But meds are no answer, they work until they do not.
Glutamate/GABA imbalance and nitric oxide will soon be recognized as the drivers of mood disorders.
I am confidant I am right because all my friends have see the change in me. Plus I no longer needs meds.
If I had you genetics I could probably see what is going on with you. Let me know if you want me to take a look: followingthedao@fastmail.com