Yes. You lose the ability to perform certain key chords (which happen to be default). Terminals do not distinguish between upper- and lower-case control keys, for example.
Thanks, but what you and hkolek are saying sounds contradictory. Are case-sensitive key chords critical, and losing them borks its workflow?
Bascially I want to give Emacs a shot, but using Evil-mode b/c I love Vim's modal edititing, but I also like working in terminals (I do a lot of remoting to cloud servers).
I guess I should just give it a shot and see how it goes.