Good list. Among the patients I see metabolic disturbances rank high on the list problems to manage. Some people complain of adverse effects of NAS such as headache, GI symptoms, but in the clinical setting, it's very hard to establish connections between NAS and metabolic syndrome manifestations like DM2.
The article says mouse fed any of 3 common NAS in water with/without glucose developed "glucose intolerance", which I take to mean above-normal glucose levels. That would point to either impaired insulin production or increased insulin resistance. I think the latter is much more likely.
This probably occurs in some humans too (among people genetically predisposed to develop DM2). Of course that's my extrapolation of the info, but seems a likely direction of future research. Getting insulin levels and measuring insulin resistance after NAS feeding are logical steps to take.
I agree with your comment and others that the role of colon microorganisms is a truly fascinating subject, and remains quite a mystery. Other research shows gut flora are distinct among host species. The evolution of these microbes appears intimately bound to the evolution of their host, but the nature of the link is unknown. Odds are unraveling the story of the numerous friends within (and all over) us will fill in important gaps in our knowledge in surprising ways.
The article says mouse fed any of 3 common NAS in water with/without glucose developed "glucose intolerance", which I take to mean above-normal glucose levels. That would point to either impaired insulin production or increased insulin resistance. I think the latter is much more likely.
This probably occurs in some humans too (among people genetically predisposed to develop DM2). Of course that's my extrapolation of the info, but seems a likely direction of future research. Getting insulin levels and measuring insulin resistance after NAS feeding are logical steps to take.
I agree with your comment and others that the role of colon microorganisms is a truly fascinating subject, and remains quite a mystery. Other research shows gut flora are distinct among host species. The evolution of these microbes appears intimately bound to the evolution of their host, but the nature of the link is unknown. Odds are unraveling the story of the numerous friends within (and all over) us will fill in important gaps in our knowledge in surprising ways.